Publications

  1. LF Montaño-Gutierrez*, M Sturrock*, IL Farquhar, K Correia, V Shahrezaei, PS Swain (pdf, SI, data, code)
    Dynamic patterns of gene expression match extracellular signals through push-pull regulation
    PLoS Genetics 21 (2025) e1011943

  2. S Esteban-Serna, T Widén, M Gwynne, I Farquhar, MR Duchen, PS Swain, S Granneman (pdf)
    A transcription termination mechanism for maintaining homogeneous protein expression
    Nucleic Acids Res 53 (2025) gkaf1199

  3. IBN Clark, MM Crane, JMJ Pietsch, PS Swain (pdf, videos)
    Protocol for measuring the responses of multiple budding yeast strains to extracellular change in parallel using a microfluidic device
    STAR Protoc 6 (2025) 104071

  4. J Hurbain, PR ten Wolde, PS Swain (pdf, SI, code, data)
    Quantifying the nuclear localization of fluorescently tagged proteins
    Bioinform Adv 5 (2025) vbaf114

  5. Y Huo, W Danecka, I Farquhar, K Mailliet, T Moses, EWJ Wallace, and PS Swain (pdf, code, data)
    The type of carbon source not the growth rate it supports can determine diauxie in Saccharomyces cerevisiae
    Commun Biol 8 (2025) 325

  6. G Terradot, E Krasnopeeva, PS Swain, and T Pilizota (pdf)
    Escherichia coli maintains pH via the membrane potential
    PRX Life 2 (2024) 043015

  7. Y Huo, H Li, X Wang, X Du, and PS Swain (pdf, software, data)
    Nunchaku: optimally partitioning data into piece-wise contiguous segments
    Bioinformatics 39 (2023) btad688

  8. JMJ Pietsch, AF Muñoz, DA Adjavon, I Farquhar, IBN Clark, and PS Swain (pdf, journal, software, data)
    Determining growth rates from bright-field images of budding cells through identifying overlaps
    eLife 12 (2023) e79812

  9. LF Montaño-Gutierrez, NM Moreno, IL Farquhar, Y Huo, L Bandiera, and PS Swain (pdf, SI, software, data)
    Analysing and meta-analysing time-series data of microbial growth and gene expression from plate readers
    PLoS Comput Biol 18 (2022) e1010138

  10. LF Montaño-Gutierrez, K Correia, and PS Swain (pdf, software, data)
    Multiple nutrient transporters enable cells to mitigate a rate-affinity tradeoff
    PLoS Comput Biol 18 (2022) e1010060

  11. A Murugan, K Husain, MJ Rust, C Hepler, J Bass, JM Pietsch, PS Swain, SG Jena, JE Toettcher, AK Chakraborty and KG Sprenger (pdf)
    Roadmap on biology in time varying environments
    Phys Biol 18 (2021) 041502

  12. N Scales and PS Swain (pdf, SI, code)
    Resolving fluorescent species by their brightness and diffusion using correlated photon-counting histograms
    PLoS One 14 (2019) e0226063

  13. E Bakker and PS Swain (pdf, data)
    Estimating numbers of intracellular molecules through analysing fluctuations in photobleaching
    Sci Rep 9 (2019) 15238

  14. B Cerulus, A Jariani, G Perez-Samper, L Vermeersch, JM Pietsch, MM Crane, AM New, B Gallone, M Roncoroni, MC Dzialo, SK Govers, JO Hendrickx, E Galle, M Coomans, P Berden, S Verbandt, PS Swain, and KJ Verstrepen (pdf, SI)
    Transition between fermentation and respiration determines history-dependent behavior in fluctuating carbon sources
    eLife 7 (2018) e39234

  15. L Bandiera, Z Hou, VB Kothamachu, E Balsa-Canto, PS Swain, and F Menolascina (pdf)
    On-line optimal input design increases the efficiency and accuracy of the modelling of an inducible synthetic promoter
    Processes 6 (2018) 148

  16. AA Granados*, JMJ Pietsch*, SA Cepeda-Humerez, IL Farquhar, G Tkacik, and PS Swain (pdf, SI, software, data)
    Distributed and dynamic intracellular organization of extracellular information
    Proc Natl Acad Sci USA 115 (2018) 6088

  17. E Bakker, PS Swain, and MM Crane (pdf, SI, software)
    Morphologically constrained and data informed cell segmentation of budding yeast
    Bioinformatics 34 (2018) 88

  18. M Hinrichsen, M Lenz, JM Edwards, OK Miller, SGJ Mochrie, PS Swain, U Schwarz-Linek, and L Regan (pdf, SI)
    A new method for post-translationally labeling proteins in live cells for fluorescence imaging and tracking
    Protein Eng Des Sel 30 (2017) 771

  19. C Josephides and PS Swain (pdf, SI)
    Predicting metabolic adaptation from networks of mutational paths
    Nat Commun 8 (2017) 685

  20. AA Granados*, MM Crane*, LF Montano-Gutierrez, RJ Tanaka, M Voliotis, and PS Swain (pdf, SI, data)
    Distributing tasks via multiple input pathways increases cellular survival in stress
    eLife 6 (2017) e21415

  21. PS Swain, K Stevenson, A Leary, LF Montano-Gutierrez, IBN Clark, J Vogel, and T Pilizota (pdf, software, data)
    Inferring time derivatives including growth rates using Gaussian processes
    Nat Commun 7 (2016) 13766

  22. K Stevenson, AF McVey, IBN Clark, PS Swain, and T Pilizota (pdf, SI)
    General calibration of microbial growth in microplate readers
    Sci Rep 6 (2016) 38828

  23. N Popovic, C Marr, and PS Swain (pdf)
    A geometric analysis of fast-slow models for stochastic gene expression
    J Math Biol 72 (2016) 87

  24. S Feng, JF Ollivier, PS Swain, and OS Soyer (pdf, SI)
    BioJazz: in silico evolution of cellular networks with unbounded complexity using rule-based modeling
    Nucleic Acids Res 43 (2015) e123

  25. AY Weisse, DA Oyarzun, V Danos, and PS Swain (pdf, SI, SBML/Matlab)
    Mechanistic links between cellular trade-offs, gene expression, and growth
    Proc Nat Acad Sci USA 112 (2015) E1038

  26. MM Crane, IBN Clark, E Bakker, S Smith, and PS Swain (pdf, SI)
    A microfluidic system for studying ageing and dynamic single-cell responses in budding yeast
    PLoS One 9 (2014) e100042

  27. CG Bowsher and PS Swain (pdf)
    Environmental sensing, information transfer, and cellular decision-making
    Curr Opin Biotechnol 28C (2014) 149

  28. CA Lichten, R White, IBN Clark, and PS Swain (pdf, software)
    Unmixing of fluorescence spectra to resolve quantitative time-series measurements of gene expression in plate readers
    BMC Biotechnol 14 (2014) 11

  29. BMC Martins and PS Swain (pdf, SI)
    Ultrasensitivity in phosphorylation-dephosphorylation cycles with little substrate
    PLoS Comput Biol 9 (2013) e1003175

  30. CG Bowsher, M Voliotis, and PS Swain (pdf, SI)
    The fidelity of dynamic signaling by noisy biomolecular networks
    PLoS Comput Biol 9 (2013) e1002965

  31. D Cottrell, PS Swain, and PF Tupper (pdf, SI)
    Stochastic branching-diffusion models for gene expression
    Proc Nat Acad Sci USA 109 (2012) 9699

  32. CG Bowsher and PS Swain (pdf, SI, summary)
    Identifying sources of variation and the flow of information in biochemical networks
    Proc Nat Acad Sci USA 109 (2012) E1320

  33. JW Young, JC Locke, A Altinok, N Rosenfeld, T Bacarian, PS Swain, E Mjolsness, and MB Elowitz (pdf)
    Measuring single-cell gene expression dynamics in bacteria using fluorescence time-lapse microscopy
    Nat Protoc 7 (2011) 80

  34. BMC Martins and PS Swain (pdf)
    Trade-offs and constraints in allosteric sensing
    PLoS Comput Biol 7 (2011) e1002261

  35. CA Lichten and PS Swain (pdf, software)
    A Bayesian method for inferring quantitative information from FRET data
    BMC Biophys 4 (2011) 10

  36. JF Ollivier, V Shahrezaei, and PS Swain (pdf, SI, software)
    Scalable rule-based modelling of allosteric proteins and biochemical networks
    PLoS Comput Biol 6 (2010) e1000975

  37. MK Malleshaiah, V Shahrezaei, PS Swain, and SW Michnick (pdf, SI)
    The scaffold protein Ste5 directly controls a switch-like mating decision in yeast
    Nature 465 (2010) 101

  38. TJ Perkins and PS Swain (pdf)
    Strategies for cellular decision-making
    Mol Syst Biol 5 (2009) 326

  39. F Siso-Nadal, JJ Fox, SA Laporte, TE Hebert, and PS Swain (pdf)
    Signaling pathways can generate robust oscillations in calcium and cAMP
    PLoS One 4 (2009) e7189

  40. V Shahrezaei and PS Swain (pdf, SI, software)
    Analytical distributions for stochastic gene expression
    Proc Nat Acad Sci USA 105 (2008) 17256
    Please note that Eqn. 13 should read F(z)= [f(z)]a = (1+b-bz)-a.

  41. V Shahrezaei and PS Swain (pdf)
    The stochastic nature of biochemical networks
    Curr Opin Biotechnol 19 (2008) 369

  42. V Shahrezaei, JF Ollivier, and PS Swain (pdf, SI, software)
    Colored extrinsic fluctuations and stochastic gene expression
    Mol Syst Biol 4 (2008) 196

  43. V Gousseva, M Simaan, SA Laporte, and PS Swain (pdf)
    Inferring the lifetime of endosomal protein complexes by fluorescence recovery after photobleaching
    Biophys J 94 (2008) 679

  44. N Rosenfeld, JW Young, U Alon, PS Swain, and MB Elowitz (pdf)
    Accurate prediction of gene feedback circuit behavior from component properties
    Mol Syst Biol 3 (2007) 143

  45. F Siso-Nadal, JF Ollivier, and PS Swain (pdf, software)
    Facile: a command-line network compiler for systems biology
    BMC Syst Biol 1 (2007) 36

  46. E Libby, TJ Perkins, and PS Swain (pdf, SI, press)
    Noisy information processing through transcriptional regulation
    Proc Nat Acad Sci USA 104 (2007) 7151

  47. P Lenz and PS Swain (pdf, SI)
    An entropic mechanism to generate highly cooperative and specific binding from protein phosphorylations
    Curr Biol 16 (2006) 2150

  48. PS Swain and A Longtin (pdf)
    Noise in genetic and neural networks
    Chaos 16 (2006) 26101
    A special Chaos issue of tutorial articles highlighting and contrasting stochastic modelling in genetic and neural systems.

  49. N Rosenfeld, TJ Perkins, U Alon, MB Elowitz, and PS Swain (pdf, software)
    A fluctuation method to quantify in vivo fluorescence data
    Biophys J 91 (2006) 759

  50. S Ramanathan and PS Swain (pdf)
    Tracing the sources of cellular variation
    Dev Cell 9 (2005) 576

  51. N Rosenfeld, JW Young, U Alon, PS Swain, and MB Elowitz (pdf, SI)
    Gene regulation at the single-cell level
    Science 307 (2005) 1962

  52. PS Swain (pdf)
    Efficient attenuation of stochasticity in gene expression through post-transcriptional control
    J Mol Biol 344 (2004) 965

  53. PS Swain, MB Elowitz, and ED Siggia (pdf, SI)
    Intrinsic and extrinsic contributions to stochasticity in gene expression
    Proc Nat Acad Sci USA 99 (2002) 12795

  54. MB Elowitz, AJ Levine, ED Siggia, and PS Swain (pdf, SI)
    Stochastic gene expression in a single cell
    Science 297 (2002) 1183

  55. PS Swain and ED Siggia (pdf)
    The role of proof-reading in signal transduction specificity
    Biophys J 82 (2002) 2928

  56. PS Swain and D Andelman (pdf)
    Supported membranes on chemically structured and rough surfaces
    Phys Rev E 63 (2001) 051911

  57. R Lipowsky, P Lenz, and PS Swain (pdf)
    Wetting and dewetting of structured and imprinted surfaces
    Colloid Surface A 161 (2000) 3

  58. PS Swain and R Lipowsky (pdf)
    Wetting between structured surfaces: liquid bridges and induced forces
    Europhys Lett 49 (2000) 203

  59. PS Swain and D Andelman (pdf)
    The influence of surface structure on membrane adhesion
    Langmuir 15 (1999) 8902

  60. PS Swain and R Lipowsky (pdf)
    Contact angles on heterogeneous surfaces: a new look at Cassie's and Wenzel's laws
    Langmuir 14 (1998) 6772

  61. PS Swain and AO Parry (pdf)
    Corrugation induced first-order wetting: an effective Hamiltonian study
    Eur Phys J B 4 (1998) 459

  62. AO Parry and PS Swain (pdf)
    Coupled Hamiltonians and three dimensional short-range wetting transitions
    Physica A 250 (1998) 167

  63. AO Parry and PS Swain (pdf)
    Multi-field effective Hamiltonian theory
    Fluid Phase Equilibr 150 (1998) 573

  64. PS Swain and AO Parry (pdf)
    Two parameters for three dimensional wetting transitions
    Europhys Lett 37 (1997) 207

  65. AO Parry and PS Swain (pdf)
    Correlation function algebra for inhomogeneous fluids
    J Phys: Condens Matter 9 (1997) 2351

  66. PS Swain and AO Parry (pdf)
    An exact solution for two dimensional wetting with a corrugated wall
    J Phys A 30 (1997) 4597

  67. AO Parry, PS Swain, and JA Fox (pdf)
    Fluid adsorption at a non-planar wall: roughness induced first-order wetting
    J Phys: Condens Matter 8 (1996) L659

  68. AO Parry, CJ Boulter, and PS Swain (pdf)
    Coupled fluctuations near critical wetting
    Phys Rev E 52 (1995) R5768


Book chapters

  1. TJ Perkins, AY Weisse, and PS Swain (pdf)
    Chance and memory
    Quantitative biology: from molecular to cellular systems (2012) edited by ME Wall (CRC Press, Boca Raton, Florida).


Lecture notes

  1. PS Swain (pdf)
    Lecture notes on stochastic models in systems biology
    arXiv (last updated 2010).